Relationship between Degree and Exacerbation of COPD in COPD Patients with Components of Metabolic Syndrome

· COPD, Journal

Nanda Aulia Putri, Oea Khairsyaf, Irvan Medison, Yessy S Sabri

Bagian Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Andalas, Padang


Background: Inflammation that occurs in patients with COPD are lung inflammation and systemic inflammation. Systemic inflammation also occurs in other chronic diseases include metabolic syndrome, cardiovascular disease, osteoporosis, diabetes, and depression. The metabolic syndrome is a collection of several components, in the form of central obesity, dyslipidemia, hypertension and insulin resistance. COPD patients accompanied by metabolic syndrome components will aggravate the condition of COPD patients. This study aimed to assess the degree of COPD and the incidence of exarcebations in COPD patients with metabolic syndrome components.
Methods: The study was conducted in 60 patients stable COPD. Spirometry examinations conducted by GOLD criteria and the criteria for metabolic syndrome was measured according to a modification NACEP-ATP III criteria for Asians. Patients were followed for three months to see the events exarcebations.
Results: The majority of COPD patients in stage II (60%). COPD patients with stage I, II, III and IV have most one components of metabolic syndrome is 3.3%, 25%, 15% and 1.7%.The frequency of most types of components metabolic syndrome is hypertension (43,8%). COPD patients without component and one component of metabolic syndrome most commonly found with no events exarcebations, while COPD patients with ≥3 components of the metabolic syndrome most comonly found with > 1 time exarcebations
Conclusions: There was no relationship with the degrees of COPD with the number of metabolic syndrome components and there is a significant relationship between the number of metabolic syndrome components with the incidence of COPD patients exarcebations. (J Respir Indo. 2016; 36: 33-40)

Keywords: Stable COPD, Degree of COPD, metabolic syndrome components, exarcebations

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