Obesity Hypoventilation Syndrome

· Article Review, Sleep Medicine

Yuniasri W,1 Wiendo Syah Putra,2 Prasenohadi,2 Menaldi Rasmin2
1Departemen Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Airlangga, RSUD Dr. Soetomo, Surabaya
2Departemen Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Indonesia, RSUP Persahabatan, Jakarta

Obesity hypoventilation syndrome (OSH) can increase patient’s mortality and morbidity and reduce the quality of life. Pathophysiology of OSH because of the increased load of breathing, weakness of the respiratory muscles, leptin resistance, impaired breathing during sleep can lead to decrease in the sensitivity of central ventilation response resulting in hypoventilation and hypercapnia. Obesity hypoventilation syndrome are obese patients who had hypercapnia (PaCO2 > 45 mmHg) without other abnormalities are found underlying the occurrence of hypoventilation. Laboratory tests need to be done are the arterial blood gas analysis, spirometry, bronchodilator test, maximal inspiratory and expiratory pressures and vital capacity in the supine position. Management of OSH consist of the treatment of respiratory disorders during sleep, surgery and pharmacotherapy. (J Respir Indo. 2016; 36: 192-7)

Keywords: Obesity, OSH, management

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