Salva Badjarad, Daniel Maranatha
Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Airlangga, RSUD Dr. Soetomo, Surabaya
Abstract
Background: Asthma is a chronic obstructive airway disease markedly by inflammation and airway hyperresponsiveness. Astma is one of causes of morbidity and mortality in Indonesia. Asthma has different manifestations of inflammatory patterns such as Th1, Th2 and an increase of neutrophil chemoattractant IL-8 related to Th17. Small airways dysfunction associated with poor asthma control.Relations of inflammatory mediators with dysfunction of small airways in asthma is still unclear. This study purpose to determine the relationship of the levels of IL-17 sputum induction with FEF25-75% in partially controlled asthma and uncontrolled. This study was aimed to asses relationship between interleukin 17 level in sputum induction with FEF25-75% in Asthma.
Methods: This is a cross sectional analytic study. Subject taken with consecutive sampling that was conducted in asthma outpatient clinic Dr Soetomo Teaching Hospital, Surabaya. All subjects were asthma patients who met the inclusion and exclusion criteria.
Results: Data from 30 subjects partially controlled asthma were 13 patients (43.3%) and uncontrolled asthma were 17 patients (56.7%). FEF 25-75% in partially controlled asthma 58.08 ± 20.48 (%) and uncontrolled asthma 40.71 ± 22.54 (%). Levels of IL-17 in partially controlled asthma 6.30 ± 2.33 (pg) and uncontrolled asthma 5.95 ± 1.92 (pg). There were no differences of levels of IL-17 on both of asthma control p-value of 0.656 (p ≥ 0.05). Spearman`s statistical test results showed no significant relationship between the levels of IL-17 with FEF25-75% with p-value of 0.971 (p <0.05).
Conclusion: There is no correlation between level of IL-17 with FEF25-75% (J Respir Indo. 2017; 37: 84-90)
Keywords: Asthma, IL-17, FEF25-75%