Effect of Calcitriol to FEV1% and The Amount of Eosinofil Blood of Asthma Patients

· Asthma, Lung Function

Dyah Nurwidiasih,1 Suradi,2 Yusup Subagio Sutanto2
1Program Studi Kedokteran Keluarga, Program Pascasarjana, Universitas Sebelas Maret, Surakarta.
2Departemen Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Sebelas Maret, Surakarta

Background: The long term goals of asthma management are to achieve symptom control and minimize the risk of future exacerbations. Achievement of asthma control is done through the the treatment of controller, reliever medication, and supplementation of vitamin D. The form of vitamin D is calcitriol (1,25 [OH] 2D3), the active form of vitamin D. the roles of vitamin D supplementation in asthma is immunomodulators, antiviral and antimicrobial, increasing the steroid response, and reducing atopy. Several studies of the effect of calcitriol have been carried out with varied results. This study was aimed to explain the effect of vitamin D on the value VEP1% and the number of blood eosinophils in asthmatics patients who were not in exacerbations.
Methods: This study is a clinical trial with a case experimental group pretest – posttest design. Subjects are asthmatics patients who are not in exacerbations in Dr. Moewardi Hospital, Surakarta in September 2015 until the sample size is met. Sampling was done by purposive sampling, a total of 32 patients were divided as 16 patients in treatment group (given calcitriol) and 16 patients as a control group (only asthma therapy).
Results: Treatment of calcitriol increased the value VEP1%, although it was not statistically significant (6.35 vs 5.74; p = 0.89), and significantly reduced the number of blood eosinophils (0,26 0.54 vs 0.68; p = 0.003).
Conclusion: Calcitriol treatment significantly reduced the blood eosinophil count and increased the value VEP1%, although it was not statistically significant. (J Respir Indo. 2017; 37: 182-7)

Keywords: Calcitriol, VEP1%, eosinophils, asthma

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