Profile of Serum C-Reactive Protein Levels in Confirmed Tuberculosis HIV Coinfection

· Biomolecular, Lung Infection

Budi Yanti, Laksmi Wulandari
Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Syiah Kuala, RSUD Dr. Zainoel Abidin, Banda Aceh
Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Airlangga, RSUD Dr. Soetomo, Surabaya

Background: Diagnosis of tuberculosis (TB) in HIV-infected patients is often difficult due to several reasons: frequently negative sputum smear; atypical radiographical findings; higher prevalence of extra-pulmonary TB, especially in inaccessible sites and clinical features that maybe similar with other opportunistic pulmonary infections. C-reactive protein is a biomarker for an active Mycobacterium tuberculosis infection. This study was aimed to determine profile of CRP level in confirmed tuberculosis HIV co-infection.
Methods: This descriptive study employed a cross sectional design. The study subject is all patients co-infected with HIV and TB who undergone ambulatory care at the unit perawatan intermediet dan penyakit infeksi (UPIPI) of the Dr. Soetomo Hospital, Surabaya in June until August 2012 and meet the criteria of inclusion and exclusion.
Results: Thirty one participants fulfilled entry criteria: 5 (16,5%) with sputum smear tuberculosis positif, 26 (83,9%) with negatif sputum smear. The median CRP quotient was 3,6 (IQR 0; 6) in the sputum smear tuberculosis positif, 4,55 (IQR 0; 37) in the group with negatif sputum smear.
Conclusion: Overall show there is increasing of CRP level in confirmed ambulatory tuberculosis HIV infection. CRP could be a useful test in combination with clinical evaluation to rule out tuberculosis in ambulatory patients. Point-of-care CRP should be further evaluated in primary care clinics. (J Respir Indo. 2017; 37: 177-81)

Keywords: CRP, HIV-AIDS, TB-HIV coinfection, sputum smear

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