Dewi Kartikaningsih, Susanthy Djajalaksana, Moch. Ridwan, Harun Al Rasyid
Departemen Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Brawijaya, Malang
Departemen Ilmu Kedokteran Fisik dan Rehabilitasi, Fakultas Kedokteran Universitas Brawijaya, Malang
Departemen Ilmu Kesehatan Masyarakat, Fakultas Kedokteran Universitas Brawijaya, Malang
Abstract
Background: Depression is a major comorbid for COPD patients and associated with decline in health status. Until now, there is no research of pulmonary rehabilitation therapies associated with oxidative stress in COPD patients with depression. The purpose of this study is to prove the influence of pulmonary rehabilitation programs toward malondialdehyde serum level and quality of life in COPD patients with depression.
Methods: Clinical study by quasi-experimental in COPD patients with depression. Fifteen patients in case group underwent pulmonary rehabilitation programs for 8 weeks, and 15 patients were taken as control group. At early of the first month, and the end of second and third month, SGRQ-C and BDI measurement was performed, and blood samples were taken to measure malondialdehyde serum level.
Results: Serum malondialdehyde level significantly increased after pulmonary rehabilitation in case group (p=0.001). There was
significant relationship between malondialdehyde level and depression in control group (p=0.015) and case group (p=0.010), and between malondialdehyde level and quality of life in control group (p=0.042) and case group (p=0.010), accompanied with influence of pulmonary rehabilitation on impact parameter of SGRQ-C (p=0.004).
Conclusion: Pulmonary rehabilitation programs increased serum malondialdehyde level, reduced depression, and improved quality of life in COPD patients with depression. (J Respir Indo. 2015; 35: 211-7)
Keywords: Pulmonary rehabilitation, COPD, Depression, Malondialdehyde, SGRQ-C