Delyuzar1, M. Najib Dahlan Lubis1, Zainuddin Amir2, Lia Kusumawati3
1Departemen Patologi Anatomik, Fakultas Kedokteran Universitas Sumatera Utara, Medan
2Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Sumatera Utara, Medan
3Departemen Mikrobiologi, Fakultas Kedokteran Universitas Sumatera Utara, Medan
Background: Sputum smear examination and X-ray images have been used to identify pulmonary tuberculosis patients. For extrapulmonary tuberculosis, it is necessary to have fine needle aspiration biopsy cytology, although sometimes there is an unusual feature of eosinophilic mass with dark brown particles suspected as TB. This study will prove that the eosinophilic mass with brown particles is accurately used as a new criterion for TB cytology diagnostics.
Methods: Through a fine needle aspiration biopsy technique, stained with Giemsa, when the eosinophilic mass is present with dark brown particles, and confirmed by PCR examination. As a comparison, other inflammations that are not TB are also confirmed by PCR. To assess the accuracy of the diagnostic tests assess the sensitivity and specificity of eosinophilic mass with dark brown particles with gold PCR examination standards.
Results: Tuberculosis cytology diagnostic through eosinophilic mass with dark brown particles gave 98.95% sensitivity and 96.97% specificity when confirmed by PCR examination using Mycobacterium tuberculosis DNA.
Conclusion: Eosinophilic masses with dark brown particles are accurately used as new criteria for TB cytology diagnostics with high sensitivity and specificity when confirmed by PCR examination. (J Respir Indo. 2017; 37: 195-8)
Keywords: eosinophilic mass, brown particles, PCR, TB, lymphadenitis