Andi Wijayanto, Susanthy Djajalaksana, Teguh R Sartono, Harun Al Rasyid
Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Brawijaya, Malang
Background: One of the main problems in patients with COPD is muscle wasting which is a significant decline in the structure and function of skeletal muscle. The purpose of this study is to look at the differences in levels of leptin, adiponectin and SGRQ score on stable COPD patients with and without muscle wasting.
Methods: A cross sectional analytic study, 32 patients with stable COPD who experienced muscle wasting and 17 patients with stable COPD who did not experience muscle wasting. The experiment was conducted in pulmonary outpatient clinic of Saiful Anwar Hospital and physiology laboratory of Medical Faculty Brawijaya University. Diagnosis of COPD was based on GOLD criteria 2015. Muscle wasting was diagnosed through examination of the BIA. Measurement of levels of leptin and adiponectin was performed using ELISA method, SGRQ scores was measured with the SGRQ questionnaire and then those two groups are compared.
Results: Leptin levels in COPD patients who experience muscle wasting s lower than in COPD patients who did not experience muscle wasting (p= 0.047). Adiponectin levels in COPD patients who experience muscle wasting is higher than in COPD patients who did not experience muscle wasting (p = 0.711).
Conclusion: There were significant differences between the levels of leptin in stable COPD patients who experienced and in patients who didn’t experience muscle wasting. There were no significant differences in adiponectin levels in stable COPD patients who experienced and who didn’t experience muscle wasting. (J Respir Indo. 2017; 37: 208-14)
Keywords : COPD, muscle wasting, leptin, adiponectin, SGRQ