Allen Widysanto, Faisal Yunus, Irawan Yusuf , Bambang Sutrisna, Suradi

Abstract
Background: Obstructive sleep apnea has been known as one of risk factor for coronary artery disease (CAD). The aim of this study
is to examine the relation of oxygen desaturation index (ODI) due to OSA and CAD.
Methods: This study included 74 OSA men who were diagnosis of CAD by previous medical examination using treadmill and CT
angiography and cardiac catheterization. Polysomnography was performed to confirm OSA diagnosis. Oxygen desaturation index
was measured automatically in the polysomnogram.
Results: Of 39 subjects (52.7%) were diagnosed as having CAD out of 74 male OSA subjects. Cut off point ODI higher than 11.09
showing a significant result with CAD (OR 3.02, relative risk 75%, sensitivity 71.79%, specificity 54.29% Likelihood ratio LR(+) 1.75,
LR(-) 0.52).
Conclusion: Oxygen desaturation index may be an important contributor for CAD in OSA. (J Respir Indo. 2012; 3: 161-6)
Keywords: Oxygen desaturation index, coronary artery disease, obstructive sleep apnea, male, risk factor

Abstrak
Latar belakang: Obstructive sleep apnea sebagai salah satu faktor risiko kejadian PJK telah banyak diteliti orang. Tujuan penelitian
ini adalah melihat hubungan oxygen desaturation index (ODI) dengan PJK pada subjek OSA laki-laki.
Metode: Studi ini melibatkan 74 orang OSA laki-laki yang didiagnosis OSA berdasarkan pemeriksaan polisomnografi. Diagnosis
PJK ditegakkan dari hasil treadmill, CT angiografi dan kateterisasi jantung. Nilai ODI ikut terukur dalam polisomnogram secara
otomatis.
Hasil: Terdapat 39 orang yang terdiagnosis PJK. Cut off point ODI lebih dari 11.09 menunjukkan hubungan yang signifikan dengan
PJK ; Odds ratio 3,02, Risiko relatif 75%, sensitivitas 71,79%, spesifisitas 54,29%, LR(+) 1,75 dan LR (–) 0,52.
Kesimpulan: Oxygen desaturation index adalah kontributor penting terhadap kejadian PJK pada subjek OSA . (J Respir Indo.
2012; 3: 161-6)
Kata kunci: Oxygen desaturation index, coronary artery disease, obstructive sleep apnea, faktor risiko, laki-laki

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